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| Nomenclature |
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Symbol:
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Fhittm1Hbn
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Name:
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fragile histidine triad gene;
targeted mutation 1, Kay Huebner
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MGI ID: |
MGI:2176611 |
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Synonyms: |
Fhit-, Fhittm2KCC |
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Gene:
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Fhit
Location:
Chr14:9550092-11162035 bp, - strand
Genetic Position: Chr14,
5.61 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61946
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A termination codon, a GFP gene and a loxP flanked neomycin selection cassette were inserted into exon 5. Immunoblot analysis showed that homozygous mouse tissues were entirely negative for the encoded protein, and immunohistochemical detection in kidney sections of homozygous mice showed absence of the protein. (J:61946)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fhit Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:61946
Fong LY et al.,
"Muir-torre-like syndrome in fhit-deficient mice"
Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4742-7
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All: |
13 reference(s)
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Analysis Tools
