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| Nomenclature |
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Symbol:
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Mpotm1Mae
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Name:
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myeloperoxidase;
targeted mutation 1, Nobuyo Maeda
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MGI ID: |
MGI:2176344 |
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Synonyms: |
Mpo- |
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Gene:
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Mpo
Location:
Chr11:87793581-87804413 bp, + strand
Genetic Position: Chr11,
52.22 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53993
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Parent Cell Line:
| BK4 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 6 and 7. Northern blot analysis on bone marrow RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Furthermore, neutrophils and monocytes of homozygous mutant mice were shown to completely lack enzyme activity. (J:53993)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mpo Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:53993
Aratani Y et al.,
"Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase."
Infect Immun 1999 Apr;67(4):1828-36
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All: |
13 reference(s)
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Analysis Tools
