Tg(Col2a1-cre)10Amc
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Col2a1-cre)10Amc
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Name:
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transgene insertion 10, Andrew P McMahon
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MGI ID: |
MGI:2176264 |
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Synonyms: |
Col2-Cre, Col2-Cre10, CRE 10 |
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Transgene:
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Tg(Col2a1-cre)10Amc
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses Cre recombinase under the control of the collagen II (Col2a1) promoter, which directs expression in all cartilagenous structures at E12.5, as well as the facial mesenchyme and the CNS. At E13.5, Cre-recombinase activity is detected in the skeletal structures of the developing appendicular, axial and cranial skeleton, such as long bones of limbs, ribs, vertebrae and skull base, as well as in the epithelial cells of kidney, pancreas, lungs, intestine and ovary.
(J:73071, J:140779)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:73071
Long F et al.,
"Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation."
Development 2001 Dec;128(24):5099-108
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All: |
8 reference(s)
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Analysis Tools
