Tg(Alb-cre)21Mgn
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Alb-cre)21Mgn
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Name:
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transgene insertion 21, Mark A Magnuson
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MGI ID: |
MGI:2176228 |
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Synonyms: |
Albcre, Alb-cre, AlbCre, albumin-cre, crAlb, CreALB |
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Transgene:
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Tg(Alb-cre)21Mgn
Location:
unknown
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Show the 5 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. (J:51826)
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Recombinase activity
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Activity in:
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liver & biliary system
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Not detected in:
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adipose tissue,
alimentary system,
cardiovascular system,
cavities & their linings,
embryo-other,
endocrine system,
hemolymphoid system,
integumental system,
limbs,
mesenchyme,
muscle,
nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
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Driver:
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Alb
Summary of all recombinase alleles
driven by Alb.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51826
Postic C et al.,
"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase."
J Biol Chem 1999 Jan 1;274(1):305-15
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All: |
361 reference(s)
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Analysis Tools
