Tg(Ins2-cre)25Mgn
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Ins2-cre)25Mgn
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Name:
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transgene insertion 25, Mark A Magnuson
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MGI ID: |
MGI:2176227 |
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Synonyms: |
Ins2cre, Ins-Cre, RIP2-cre, Rip-cre, RIPCre, [RIP]-Cre, RIP Cre |
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Transgene:
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Tg(Ins2-cre)25Mgn
Location:
unknown
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Show the 3 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses Cre recombinase under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. (J:51826)
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Recombinase activity
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Activity in:
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adipose tissue,
alimentary system,
branchial arches,
cardiovascular system,
endocrine system,
integumental system,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
sensory organs,
skeletal system,
tail
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Not detected in:
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cavities & their linings,
extraembryonic component,
hemolymphoid system,
limbs,
respiratory system
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Driver:
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Ins2
Summary of all recombinase alleles
driven by Ins2.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51826
Postic C et al.,
"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase."
J Biol Chem 1999 Jan 1;274(1):305-15
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All: |
116 reference(s)
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Analysis Tools
