Tg(Nes-cre)1Kln
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Nes-cre)1Kln
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Name:
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transgene insertion 1, Rudiger Klein
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MGI ID: |
MGI:2176173 |
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Synonyms: |
n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre) |
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Transgene:
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Tg(Nes-cre)1Kln
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Show the 13 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursor. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). (J:57315, J:133340, J:164338)
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Recombinase activity
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Activity in:
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adipose tissue,
alimentary system,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs
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Not detected in:
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branchial arches,
embryo-other,
extraembryonic component,
limbs,
skeletal system
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Driver:
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Nes
Summary of all recombinase alleles
driven by Nes.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:57315
Tronche F et al.,
"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety."
Nat Genet 1999 Sep;23(1):99-103
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All: |
417 reference(s)
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Analysis Tools
