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| Nomenclature |
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Symbol:
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Itgb3tm1Hyn
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Name:
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integrin beta 3;
targeted mutation 1, Richard Hynes
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MGI ID: |
MGI:2175913 |
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Synonyms: |
beta3-, Beta3, beta3 KO |
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Gene:
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Itgb3
Location:
Chr11:104608000-104670476 bp, + strand
Genetic Position: Chr11,
67.84 cM
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Survival of Itgb3tm1Hyn/Itgb3tm1Hyn mice is compromised due to placental defects and hemorrhage
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52262
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced 1.4 kb of sequence including exons I and II. FACS, immunoprecipitation, and immunofluorescence analyses did not detect protein expression in platelets and MEFs from homozygous mutant animals. (J:52262)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:52262
Hodivala-Dilke KM et al.,
"Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival."
J Clin Invest 1999 Jan;103(2):229-38
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All: |
69 reference(s)
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Analysis Tools
