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| Nomenclature |
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Symbol:
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Gpc3tm1Snd
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Name:
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glypican 3;
targeted mutation 1, Scott Saunders
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MGI ID: |
MGI:2159355 |
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Synonyms: |
Gpc3tm108Sau |
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Gene:
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Gpc3
Location:
ChrX:52272426-52613950 bp, - strand
Genetic Position: ChrX,
28.74 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64330
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced genomic sequences corresponding to the transcriptional and translational start sites, and encoding the signal peptide and first 33 amino acids of the mature protein. Western blot analysis on purified proteoglycan extracts derived from E16.5 liver of male hemizygous mice confirmed that no detectable protein is produced from this allele. (J:64330)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gpc3 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:64330
Paine-Saunders S et al.,
"glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development."
Dev Biol 2000 Sep 1;225(1):179-87
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All: |
3 reference(s)
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Analysis Tools
