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| Nomenclature |
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Symbol:
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Neurod6tm1Kan
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Name:
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neurogenic differentiation 6;
targeted mutation 1, Klaus-Armin Nave
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MGI ID: |
MGI:2159008 |
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Synonyms: |
NEX - |
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Gene:
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Neurod6
Location:
Chr6:55677818-55681263 bp, - strand
Genetic Position: Chr6,
27.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45777
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing most of the coding region, including amino acids 53-337 encoding the bHLH domain. Northern blot analysis on brain RNA derived from P5 homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:45777)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Neurod6 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:45777
Schwab MH et al.,
"Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice."
J Neurosci 1998 Feb 15;18(4):1408-18
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All: |
2 reference(s)
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Analysis Tools
