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| Nomenclature |
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Symbol:
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Gja1tm1Dlg
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Name:
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gap junction protein, alpha 1;
targeted mutation 1, Brian R Duling
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MGI ID: |
MGI:2159007 |
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Synonyms: |
VEC Cx43 KO |
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Gene:
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Gja1
Location:
Chr10:56377300-56390419 bp, + strand
Genetic Position: Chr10,
28.64 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71092
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted flanking exon 2. A neomycin selection cassette and thymidine kinase gene that were also inserted 3' to the loxP sites were removed by transient cre recombinase expression in ES cells prior to the production of chimeric mice. Western blot and immunohistochemistry analysis on homozygous mice confirmed that there were no detectable changes in the expression of the encoded protein. (J:71092)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:71092
Liao Y et al.,
"Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice."
Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9989-94
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All: |
11 reference(s)
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Analysis Tools
