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| Nomenclature |
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Symbol:
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Oprm1tm1Kff
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Name:
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opioid receptor, mu 1;
targeted mutation 1, Brigitte L Kieffer
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MGI ID: |
MGI:2159000 |
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Synonyms: |
MOR- |
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Gene:
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Oprm1
Location:
Chr10:6758506-7038198 bp, + strand
Genetic Position: Chr10,
1.85 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36241
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Parent Cell Line:
| P1 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 2. Binding assays on brain of homozygous animals confirmed that no functional protein was made from this allele. (J:36241)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:36241
Matthes HW et al.,
"Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [see comments]"
Nature 1996 Oct 31;383(6603):819-23
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All: |
38 reference(s)
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Analysis Tools
