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| Nomenclature |
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Symbol:
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Ece1tm1Reh
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Name:
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endothelin converting enzyme 1;
targeted mutation 1, Robert E Hammer
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MGI ID: |
MGI:2158947 |
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Synonyms: |
ECE-1 - |
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Gene:
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Ece1
Location:
Chr4:137862237-137965229 bp, + strand
Genetic Position: Chr4,
70.02 cM
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Cardiac defects in Ece1tm1Reh/Ece1tm1Reh and Ece1tm1Reh/Ece1tm1Reh Ece2tm1Ywa/Ece2tm1Ywa embryos
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46640
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced an exon containing coding sequences upstream of the zinc-binding motif. Western blot analysis on membrane preparations of homozygous E17-19 embryos confirmed that no detectable encoded protein was produced from this allele. (J:46640)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:46640
Yanagisawa H et al.,
"Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene."
Development 1998 Mar;125(5):825-36
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All: |
9 reference(s)
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Analysis Tools
