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| Nomenclature |
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Symbol:
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Thbdtm2Rdr
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Name:
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thrombomodulin;
targeted mutation 2, Robert D Rosenberg
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MGI ID: |
MGI:2158818 |
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Synonyms: |
Thbd-, TMlacZ, TMlacZ |
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Gene:
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Thbd
Location:
Chr2:148404466-148408188 bp, - strand
Genetic Position: Chr2,
73.45 cM
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Venous and arterial thrombi and extravascular fibrinogen deposition in the lungs of Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74855
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A lacZ gene and neomycin selection cassette was inserted into the start codon of the gene. A hybrid mRNA molecule, consisting of 157 nucleotides of the endogenous 5' untranslated mRNA followed by the lacZ open reading frame, was transcribed from this allele. (J:71269, J:74855)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Thbd Mutation:
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1 strain or line available |
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| References |
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Original: |
J:74855
Weiler-Guettler H et al.,
"Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus."
Circ Res 1996 Feb;78(2):180-7
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All: |
9 reference(s)
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Analysis Tools
