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| Nomenclature |
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Symbol:
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Sox9tm1Crm
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Name:
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SRY-box containing gene 9;
targeted mutation 1, Benoit de Crombrugghe
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MGI ID: |
MGI:2158693 |
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Gene:
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Sox9
Location:
Chr11:112782224-112787760 bp, + strand
Genetic Position: Chr11,
77.27 cM
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Skeletal malformations of Sox9tm1Crm/Sox9+ mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69875
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 300 bp DNA fragment containing part of exon 1 was replaced with an IRES-lacZ gene followed by a neomycin selection cassette. Northern blot and western blot analysis on chondrocytes derived from heterozygous mice demonstrated reduced expression of both the encoded transcript and protein. (J:69875, J:75041)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sox9 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:75041
Bi W et al.,
"Sox9 is required for cartilage formation."
Nat Genet 1999 May;22(1):85-9
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All: |
4 reference(s)
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Analysis Tools
