H2-Ab1tm1Gru
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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H2-Ab1tm1Gru
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Name:
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histocompatibility 2, class II antigen A, beta 1;
targeted mutation 1, Michael J Grusby
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MGI ID: |
MGI:2158420 |
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Synonyms: |
Ab1tm1Gru, Abb-, Abbeta-, Abbtm1, Abeta-, Abetab-, C2-, H2-Ab1-, H2-Ab1tm1Glm, I-Ab-, IAb-, IAbeta-, I-Abetab-, [KO]Abb, MHC class II-, MHC-II-deficient, mII- |
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Gene:
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H2-Ab1
Location:
Chr17:34263209-34269418 bp, + strand
Genetic Position: Chr17,
17.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74418
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:74418)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)
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| References |
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Original: |
J:74418
Grusby MJ et al.,
"Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice."
Science 1991 Sep 20;253(5026):1417-20
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All: |
245 reference(s)
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Analysis Tools
