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| Nomenclature |
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Symbol:
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Apoetm3(APOE*4)Mae
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Name:
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apolipoprotein E;
targeted mutation 3, Nobuyo Maeda
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MGI ID: |
MGI:2158398 |
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Synonyms: |
4, apoe4, Apoe4, APOE*4, apoE4-KI, apoE4 TR, Apoetm3(APOE)Mae, E4, TgH/ApoE4/N8, TRE4 |
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Gene:
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Apoe
Location:
Chr7:19696109-19699166 bp, - strand
Genetic Position: Chr7,
9.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74417
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A DNA fragment containing exons 2-4 of the human APOE gene (the APOE4 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. (J:74417)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apoe Mutation:
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54 strains or lines available |
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| References |
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Original: |
J:74417
Knouff C et al.,
"Apo E structure determines VLDL clearance and atherosclerosis risk in mice."
J Clin Invest 1999 Jun;103(11):1579-86
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All: |
43 reference(s)
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Analysis Tools
