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| Nomenclature |
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Symbol:
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Mecp2tm1.1Jae
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Name:
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methyl CpG binding protein 2;
targeted mutation 1.1, Rudolf Jaenisch
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MGI ID: |
MGI:2158354 |
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Synonyms: |
Mecp1lox, Mecp2tm1-1Jae |
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Gene:
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Mecp2
Location:
ChrX:74026592-74085690 bp, - strand
Genetic Position: ChrX,
37.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67909
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele is a derivative of Mecp2tm1Jae in which exon 3 is deleted by Cre mediated recombination in a germline transmissible event. Mice carrying Mecp2tm1Jae were mated to transgenic mice carrying a cre transgene under the control of a nestin promoter. This promoter was active in the male and female germline as well as the brain, and progeny of the cross were screened for deletion of exon 3. (J:67909)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67909
Chen RZ et al.,
"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice."
Nat Genet 2001 Mar;27(3):327-31
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All: |
46 reference(s)
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Analysis Tools
