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| Nomenclature |
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Symbol:
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Mecp2tm1Jae
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Name:
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methyl CpG binding protein 2;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:2158353 |
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Synonyms: |
Mecp2lox |
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Gene:
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Mecp2
Location:
ChrX:74026592-74085690 bp, - strand
Genetic Position: ChrX,
37.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67909
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted flanking exon 3 as follows: A single loxP site was inserted 5' to exon 3 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted 3' to exon 3. The selection cassette was removed in ES cells by Cre-mediated recombination prior to the production of chimeric mice, leaving a single loxP site in place of the selection cassette. (J:67909)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67909
Chen RZ et al.,
"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice."
Nat Genet 2001 Mar;27(3):327-31
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All: |
9 reference(s)
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Analysis Tools
