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| Nomenclature |
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Symbol:
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Ccr2tm1Mae
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Name:
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chemokine (C-C motif) receptor 2;
targeted mutation 1, Nobuyo Maeda
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MGI ID: |
MGI:2158345 |
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Synonyms: |
CCR2-, Ccr2tm1Unc |
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Gene:
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Ccr2
Location:
Chr9:124101950-124113557 bp, + strand
Genetic Position: Chr9,
75.05 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44561
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted in reverse transcriptional orientation in front of the coding sequence for the first transmembrane domain of the encoded protein. Competitive binding assays demonstrated a reduction in specific binding of labeled ligand to peritoneal exudate cells derived from homozygous mice. (J:44561)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Age-related macular degeneration (J:147328)
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| References |
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Original: |
J:44561
Kuziel WA et al.,
"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2."
Proc Natl Acad Sci U S A 1997 Oct 28;94(22):12053-8
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All: |
114 reference(s)
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Analysis Tools
