|
|
| Nomenclature |
|
Symbol:
|
Ccr2tm1Ifc
|
|
Name:
|
chemokine (C-C motif) receptor 2;
targeted mutation 1, Israel F Charo
|
|
MGI ID: |
MGI:2158213 |
|
Synonyms: |
CCR2-, Cmkbr2tm1Kuz |
|
Gene:
|
Ccr2
Location:
Chr9:124101950-124113557 bp, + strand
Genetic Position: Chr9,
75.05 cM, cytoband F
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:44345
|
|
Parent Cell Line:
| RF8 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The coding region and 3' untranslated region are replaced with a polII-neo cassette. Absence of transcript was confirmed by RT-PCR using mRNA isolated from spleens and thioglycolate elicited peritoneal exudate cells of homozygous mutant animals. (J:44345)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:44345
Boring L et al.,
"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice."
J Clin Invest 1997 Nov 15;100(10):2552-61
|
|
All: |
128 reference(s)
|
|
Analysis Tools
