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| Nomenclature |
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Symbol:
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Ift88Tg737Rpw
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Name:
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intraflagellar transport 88;
transgene insertion 737, Richard P Woychik
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MGI ID: |
MGI:2157527 |
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Synonyms: |
Ift88orpk, orpk, Tg737orpk, Tg737orpk, Tg737(o)(rpk), Tg737Rpw, TgN737Rpw, TgN(Imorpk)737Rpw |
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Gene:
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Ift88
Location:
Chr14:57424062-57517936 bp, + strand
Genetic Position: Chr14,
30.1 cM
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Insertion |
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Mutation details: A random transgene insertional event resulted in the deletion of approximately 2.7kb at the transgene insertion site in an intron of the gene, but no exons were deleted. Northern blot analysis revealed that expression of a 3.2 and 7.0kb transcript was abolished in RNA from all tissues derived from homozygous mice. The allele is hypomorphic. (J:18508)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ift88 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:18508
Moyer JH et al.,
"Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice."
Science 1994 May 27;264(5163):1329-33
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All: |
44 reference(s)
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Analysis Tools
