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| Nomenclature |
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Symbol:
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Apoa4tm1Bres
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Name:
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apolipoprotein A-IV;
targeted mutation 1, Jan L Breslow
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MGI ID: |
MGI:2157162 |
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Synonyms: |
apoA-IV - |
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Gene:
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Apoa4
Location:
Chr9:46240696-46243459 bp, + strand
Genetic Position: Chr9,
25.36 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43015
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.1kb genomic fragment containing exon 1 and intron 1 was replaced with a neomycin selection cassette. No transcript was detectable in northern blot analysis on intestinal RNA from homozygous mice, and western blot analysis demonstrated that no stable protein was detectable in plasma of homozygous mice. (J:43015)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:43015
Weinstock PH et al.,
"Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice."
J Lipid Res 1997 Sep;38(9):1782-94
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All: |
8 reference(s)
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Analysis Tools
