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| Nomenclature |
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Symbol:
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Lyntm1Ard
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Name:
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Yamaguchi sarcoma viral (v-yes-1) oncogene homolog;
targeted mutation 1, Ashley R Dunn
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MGI ID: |
MGI:2157129 |
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Synonyms: |
Lyn- |
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Gene:
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Lyn
Location:
Chr4:3678115-3813122 bp, + strand
Genetic Position: Chr4,
2.05 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29356
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced ~11.5kb of sequence, including the promoter and associated regulatory sequences. RT-PCR analysis of liver did not detect wild-type transcript in homozygous mutant mice. Immunoprecipitation and kinase assays of liver and spleen did not detect LYN autokinase activity in homozygous mutant mice. (J:29356)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lyn Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:29356
Hibbs ML et al.,
"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease."
Cell 1995 Oct 20;83(2):301-11
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All: |
29 reference(s)
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Analysis Tools
