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| Nomenclature |
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Symbol:
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Pax8tm1Pgr
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Name:
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paired box gene 8;
targeted mutation 1, Peter Gruss
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MGI ID: |
MGI:2156985 |
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Synonyms: |
Pax8- |
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Gene:
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Pax8
Location:
Chr2:24420551-24475599 bp, - strand
Genetic Position: Chr2,
16.43 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47310
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The vector containing a neo cassette was targeted to exon 2. A thymidine kinase gene was inserted at the 3' end of the construct. This leads to complete inactivation as the putative splicing from exon 1 to exon 3 renders the codons out of frame, terminating after 11 heterologous amino acids. (J:47310)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Expression |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:47310
Mansouri A et al.,
"Follicular cells of the thyroid gland require Pax8 gene function."
Nat Genet 1998 May;19(1):87-90
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All: |
27 reference(s)
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Analysis Tools
