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| Nomenclature |
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Symbol:
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Ppp3r1tm1Stl
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Name:
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protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I);
targeted mutation 1, Susumu Tonegawa
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MGI ID: |
MGI:2156983 |
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Synonyms: |
fCNB1, PP2B-loxP |
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Gene:
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Ppp3r1
Location:
Chr11:17159263-17200375 bp, + strand
Genetic Position: Chr11,
9.71 cM, cytoband A3.1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73203
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Homologous recombination flanked the three major coding exons, exons 2-4, with a loxP site and a LFNT cassette. The LFNT cassette consisted of PGK-neomycin and HSV-thymidine kinase selection sequences flanked by a pair of loxP sites and a pair of frt sites. Cre- or Flp-mediated recombination in ES cells removed the PGK-neomycin and HSV-thymidine kinase sequences prior to production of chimeras. (J:73203)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73203
Zeng H et al.,
"Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory."
Cell 2001 Nov 30;107(5):617-29
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All: |
7 reference(s)
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Analysis Tools
