|
|
| Nomenclature |
|
Symbol:
|
Csf3rtm1Eur
|
|
Name:
|
colony stimulating factor 3 receptor (granulocyte);
targeted mutation 1, Erasmus University Rotterdam
|
|
MGI ID: |
MGI:2156882 |
|
Synonyms: |
gcsfrdelta715 |
|
Gene:
|
Csf3r
Location:
Chr4:126024550-126044440 bp, + strand
Genetic Position: Chr4,
59.77 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:48503
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Nucleotide substitutions |
| |
|
Mutation details: A nonsense mutation was introduced into the mouse gene at codon 715 by homologous recombination. The mutation is equivalent to that identified in humans with severe chronic neutropenia (SCN). (J:48503)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:48503
Hermans MH et al.,
"Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia."
Blood 1998 Jul 1;92(1):32-9
|
|
All: |
2 reference(s)
|
|
Analysis Tools
