|
|
| Nomenclature |
|
Symbol:
|
Zic2tm1Jaru
|
|
Name:
|
zinc finger protein of the cerebellum 2;
targeted mutation 1, Jun Aruga
|
|
MGI ID: |
MGI:2156825 |
|
Synonyms: |
Zic2kd |
|
Gene:
|
Zic2
Location:
Chr14:122475435-122479852 bp, + strand
Genetic Position: Chr14,
65.97 cM
|
|
Neural tube defects found in Zic2tm1Jaru/Zic2tm1Jaru mice
Show the 2 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:60644
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (other) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A gene targeting event was designed to replace the first exon containing the start codon and encoding three of the five zinc fingers. However, unexpected recombination resulted in an allele with reduced expression. The allele retained exon 1 with the neomycin-resistance marker in the first intron, shown by Southern blot. This resulted in reduction (knockdown, kd) of Zic2 expression. (J:60644)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:60644
Nagai T et al.,
"Zic2 regulates the kinetics of neurulation."
Proc Natl Acad Sci U S A 2000 Feb 15;97(4):1618-23
|
|
All: |
10 reference(s)
|
|
Analysis Tools
