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| Nomenclature |
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Symbol:
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Wrntm1Led
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Name:
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Werner syndrome homolog (human);
targeted mutation 1, Philip Leder
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MGI ID: |
MGI:2156622 |
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Synonyms: |
Wrndeltahel, WS |
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Gene:
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Wrn
Location:
Chr8:33234384-33385527 bp, - strand
Genetic Position: Chr8,
20.3 cM, cytoband A4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48424
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3 and 4 were replaced with a neomycin selection cassette. The targeted allele is expected to express a fully translated protein that lacks 121 amino acids of the helicase domain. (J:48424)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wrn Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:48424
Lebel M et al.,
"A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity."
Proc Natl Acad Sci U S A 1998 Oct 27;95(22):13097-102
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All: |
8 reference(s)
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Analysis Tools
