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| Nomenclature |
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Symbol:
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Brca2tm1Brn
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Name:
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breast cancer 2;
targeted mutation 1, Anton Berns
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MGI ID: |
MGI:2156556 |
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Synonyms: |
Brca2F11, Brca2F11F |
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Gene:
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Brca2
Location:
Chr5:150522630-150569746 bp, + strand
Genetic Position: Chr5,
89.52 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73028
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted flanking exon 11 by homologous recombination. Subsequent Cre-mediated recombination in ES cells excised an adjacent PGK-neomycin and thymidine kinase cassette prior to the production of chimeric mice. (J:73028)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73028
Jonkers J et al.,
"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer."
Nat Genet 2001 Dec;29(4):418-25
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All: |
14 reference(s)
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Analysis Tools
