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| Nomenclature |
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Symbol:
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Adamts1tm1Hku
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Name:
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a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1;
targeted mutation 1, Hiroki Kurihara
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MGI ID: |
MGI:2156168 |
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Synonyms: |
ADAMTS-1 - |
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Gene:
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Adamts1
Location:
Chr16:85793827-85803113 bp, - strand
Genetic Position: Chr16,
48.2 cM, cytoband C3-C5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62260
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.6kb genomic fragment containing exons 2-4 was replaced with a neomycin selection cassette. RT-PCR analysis confirmed that the encoded transcript was not present in detectable levels in RNA derived from kidney of homozygous mice. (J:62260)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Adamts1 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:62260
Shindo T et al.,
"ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function [see comments]"
J Clin Invest 2000 May;105(10):1345-52
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All: |
1 reference(s)
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Analysis Tools
