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| Nomenclature |
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Symbol:
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Ptentm1Hwu
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Name:
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phosphatase and tensin homolog;
targeted mutation 1, Hong Wu
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MGI ID: |
MGI:2156086 |
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Synonyms: |
Ptenex5lox, PTENF, Ptenfl, Ptenflox, Ptenfx, Ptenlox, Ptenloxp |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75117
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Parent Cell Line:
| LW1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP flanked hygromycin resistance cassette was inserted 5' to exon 5, and a single loxP site was inserted 3' to exon 5, which encodes the phosphatase domain. The hygromycin cassette was removed in ES cells by transient Cre recombinase expression prior to the production of chimeric mice, leaving a single loxP site in place of the cassette. These insertions do not appear to have any effect on the normal function of the gene.
(J:75117)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Chronic intestinal pseudoobstruction J:155110.
Phenotypic Similarity to Human Syndrome: Granulosa cell tumor of the testis (GCTT) J:149060.
Phenotypic Similarity to Human Syndrome: Granulosa cell tumor (GCT) J:142150.
Phenotypic Similarity to Human Syndrome: Glioblastoma J:172585.
Phenotypic Similarity to Human Syndrome: B cell lymphoma J:166155.
Phenotypic Similarity to Human Syndrome: Astrocytoma J:134611
Phenotypic Similarity to Human Syndrome: Thyroid Carcinoma (J:177181)
Phenotypic Similarity to Human Syndrome: Granulosa cell tumor (GCT) J:186144
Phenotypic Similarity to Human Syndrome: Granulosa cell tumor of the testis (GCTT) J:186144
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| References |
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Original: |
J:75117
Lesche R et al.,
"Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene."
Genesis 2002 Feb;32(2):148-9
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All: |
188 reference(s)
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Analysis Tools
