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| Nomenclature |
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Symbol:
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Nbntm1Nus
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Name:
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nibrin;
targeted mutation 1, Andre Nussenzweig
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MGI ID: |
MGI:2156049 |
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Synonyms: |
NBS1- |
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Gene:
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Nbn
Location:
Chr4:15957925-15992589 bp, + strand
Genetic Position: Chr4,
6.66 cM, cytoband A
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:68993
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 2kb of gene sequence spanning the promoter, exon 1 (including the translation initiation codon), and 700 bp of intron 1. (J:68993)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nbn Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:68993
Zhu J et al.,
"Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice."
Curr Biol 2001 Jan 23;11(2):105-9
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All: |
5 reference(s)
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Analysis Tools
