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| Nomenclature |
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Symbol:
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Acvrl1tm1Enl
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Name:
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activin A receptor, type II-like 1;
targeted mutation 1, En Li
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MGI ID: |
MGI:2155980 |
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Synonyms: |
Acvrl1-, ALK1-, Alk1neo |
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Gene:
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Acvrl1
Location:
Chr15:101128522-101145336 bp, + strand
Genetic Position: Chr15,
56.41 cM, cytoband F3
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Abnormal yolk sac and embryo morphology of Acvrl1tm1Enl/Acvrl1tm1Enl mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61177
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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A PGK-neomycin selection cassette was inserted into exon 8, which encodes kinase subdomain V. (J:61177)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Acvrl1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:61177
Oh SP et al.,
"Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis."
Proc Natl Acad Sci U S A 2000 Mar 14;97(6):2626-31
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All: |
6 reference(s)
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Analysis Tools
