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| Nomenclature |
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Symbol:
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Psen1tm1Jzt
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Name:
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presenilin 1;
targeted mutation 1, Joe Z Tsien
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MGI ID: |
MGI:2155978 |
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Synonyms: |
PS1 (f) |
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Gene:
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Psen1
Location:
Chr12:83688563-83735199 bp, + strand
Genetic Position: Chr12,
38.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73252
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette and a single loxP site were inserted 3' to exon 4, and a single loxP site was inserted 5' to exon 4. (J:73252)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Psen1 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:73252
Feng R et al.,
"Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces."
Neuron 2001 Dec 6;32(5):911-26
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All: |
14 reference(s)
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Analysis Tools
