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| Nomenclature |
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Symbol:
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Abcc1tm1Bor
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Name:
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ATP-binding cassette, sub-family C (CFTR/MRP), member 1;
targeted mutation 1, Piet Borst
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MGI ID: |
MGI:2155908 |
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Synonyms: |
mrp-, mrp1-, MRP1- |
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Gene:
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Abcc1
Location:
Chr16:14361558-14475737 bp, + strand
Genetic Position: Chr16,
9.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44110
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A hygromycin selection cassette replaced sequences encoding the first ATP binding domain. No full length or truncated protein was detected in western blots on extracts derived from a variety of tissues from homozygous mice. (J:44110)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abcc1 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:44110
Wijnholds J et al.,
"Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein."
Nat Med 1997 Nov;3(11):1275-9
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All: |
16 reference(s)
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Analysis Tools
