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| Nomenclature |
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Symbol:
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Pbx1tm1Mlc
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Name:
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pre B cell leukemia homeobox 1;
targeted mutation 1, Michael L Cleary
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MGI ID: |
MGI:2155612 |
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Synonyms: |
Pbx1- |
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Gene:
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Pbx1
Location:
Chr1:168153527-168432270 bp, - strand
Genetic Position: Chr1,
75.95 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71996
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a PGK-neomycin resistance cassette into exon 3, upstream of sequences encoding the homeodomain, disrupted the gene. Western blot analysis using a monoclonal antibody specific for the most abundunt isoform of the protein did not detect any protein product in homozygous mutant E16 embryos. Immunohistochemical analysis using this same antibody did not detect nuclear or cytoplasmic expression in limb buds of E11.5 homozygous mutant embryos. (J:71996)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pbx1 Mutation:
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19 strains or lines available |
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| References |
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Original: |
J:71996
Selleri L et al.,
"Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation."
Development 2001 Sep;128(18):3543-57
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All: |
26 reference(s)
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Analysis Tools
