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| Nomenclature |
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Symbol:
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Tfebtm1Est
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Name:
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transcription factor EB;
targeted mutation 1, Eirikur Steingrimsson
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MGI ID: |
MGI:2155473 |
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Synonyms: |
TfebFcr |
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Gene:
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Tfeb
Location:
Chr17:47737030-47792419 bp, + strand
Genetic Position: Chr17,
23.99 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50513
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 4kb genomic fragment containing sequences encoding the bHLH-Zip domains was replaced by a neomycin resistance cassette in the opposite transcriptional orientation. RT-PCR analysis indicated that a truncated transcript is produced from this allele, but no active protein is predicted to be produced. (J:50513)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tfeb Mutation:
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28 strains or lines available |
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| References |
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Original: |
J:50513
Steingrimsson E et al.,
"The bHLH-Zip transcription factor Tfeb is essential for placental vascularization."
Development 1998 Dec;125(23):4607-16
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All: |
2 reference(s)
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Analysis Tools
