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| Nomenclature |
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Symbol:
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Hsf1tm1Ijb
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Name:
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heat shock factor 1;
targeted mutation 1, Ivor J Benjamin
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MGI ID: |
MGI:2155444 |
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Synonyms: |
Hsf1- |
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Gene:
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Hsf1
Location:
Chr15:76477445-76500972 bp, + strand
Genetic Position: Chr15,
35.95 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73593
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Parent Cell Line:
| KG-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.8kb genomic fragment containing all or part of 6 exons was replaced by a neomycin resistance cassette. These sequences encode half the DNA binding domain and the adjacent oligomerization domain of the protein. Northern blot analysis on RNA derived from homozygous embryonic cells demonstated that a mutant, truncated transcript was produced from this allele. However, western blot analysis indicated that no protein was detectable in cells derived from homozygous embryos. (J:73593)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73593
McMillan DR et al.,
"Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis."
J Biol Chem 1998 Mar 27;273(13):7523-8
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All: |
37 reference(s)
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Analysis Tools
