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| Nomenclature |
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Symbol:
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Myo7a816SB
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Name:
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myosin VIIA;
shaker 816SB
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MGI ID: |
MGI:2155423 |
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Synonyms: |
Myo7ash1-2R, sh1816SB, sh1OR-816SB |
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Gene:
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Myo7a
Location:
Chr7:98051060-98119524 bp, - strand
Genetic Position: Chr7,
53.57 cM
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Mutation
origin |
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Strain of Origin:
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BALB/cRl
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutations: | |
Inversion, Insertion |
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Mutation details: A 16 nt inversion and substitution of two A nucleotides with a single G resulted in a deletion of ten amino acids in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 63% of the normal level of the protein was expressed. (J:49926)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:10283
Rinchik EM et al.,
"A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis."
Proc Natl Acad Sci U S A 1990 Feb;87(3):896-900
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All: |
6 reference(s)
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Analysis Tools
