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| Nomenclature |
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Symbol:
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Myo7a4626SB
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Name:
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myosin VIIA;
shaker 4626SB
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MGI ID: |
MGI:2155422 |
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Synonyms: |
Myo7ash1-5R, sh14626SB, sh1OR-4626SB, shaker-1 |
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Gene:
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Myo7a
Location:
Chr7:98051060-98119524 bp, - strand
Genetic Position: Chr7,
53.57 cM
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Cochlear hair cell abnormalities in Myo7aHdb/Myo7a+, Myo7aHdb/Myo7a+ Myo7a4626SB/Myo7a+, and Myo7ash1/Myo7ash1 mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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BALB/cRl
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: A C-to-T transition mutation is predicted to result in a glycine to stop codon change at position 720 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:54592
Rinchik EM et al.,
"N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations."
Genetics 1999 May;152(1):373-83
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All: |
23 reference(s)
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Analysis Tools
