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| Nomenclature |
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Symbol:
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Myo7a4494SB
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Name:
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myosin VIIA;
shaker 4494SB
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MGI ID: |
MGI:2155421 |
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Synonyms: |
Myo7ash1-4R, sh14494SB, sh1OR-4494SB |
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Gene:
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Myo7a
Location:
Chr7:98051060-98119524 bp, - strand
Genetic Position: Chr7,
53.57 cM
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Mutation
origin |
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Strain of Origin:
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BALB/cRl
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Inversion |
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Mutation details: A small 6 nt inversion and substitution of two T nucleotides with a single A resulted in a frameshift and introduction of a stop codon 5 amino acids downstream in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73419
Rinchik EM et al.,
"Reverse genetics in the mouse and its application to the study of deafness."
Ann N Y Acad Sci 1991;630():80-92
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All: |
5 reference(s)
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Analysis Tools
