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| Nomenclature |
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Symbol:
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Sgcgtm1Mcn
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Name:
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sarcoglycan, gamma (dystrophin-associated glycoprotein);
targeted mutation 1, Elizabeth M McNally
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MGI ID: |
MGI:2154693 |
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Synonyms: |
gsg - |
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Gene:
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Sgcg
Location:
Chr14:61221059-61258490 bp, - strand
Genetic Position: Chr14,
32.27 cM, cytoband C3
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Stunted growth and abnormal stance in Sgcgtm1Mcn/Sgcgtm1Mcn mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49871
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exon 2, which encodes the initiation codon, the cytoplasmic tail and the transmembrane domain of the encoded protein. (J:49871)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sgcg Mutation:
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1 strain or line available |
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| References |
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Original: |
J:49871
Hack AA et al.,
"Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin."
J Cell Biol 1998 Sep 7;142(5):1279-87
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All: |
13 reference(s)
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Analysis Tools
