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| Nomenclature |
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Symbol:
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Sgcbtm1Oza
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Name:
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sarcoglycan, beta (dystrophin-associated glycoprotein);
targeted mutation 1, Eijiro Ozawa
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MGI ID: |
MGI:2154611 |
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Synonyms: |
BSG - |
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Gene:
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Sgcb
Location:
Chr5:73632749-73647713 bp, - strand
Genetic Position: Chr5,
38.89 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57590
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 2. Northern blot analysis demonstrated that the transcript was not detectable in total RNA derived from skeletal muscle of homozygous mice, and western blot analysis confirmed that the protein was not detectable in microsomal preparations of skeletal muscle of homozygous mice. (J:57590)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57590
Araishi K et al.,
"Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice."
Hum Mol Genet 1999 Sep;8(9):1589-98
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All: |
2 reference(s)
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Analysis Tools
