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| Nomenclature |
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Symbol:
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Itgb1tm1Lscd
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Name:
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integrin beta 1 (fibronectin receptor beta);
targeted mutation 1, Caroline H Damsky
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MGI ID: |
MGI:2154540 |
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Synonyms: |
beta1-null, Itgbeta1- |
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Gene:
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Itgb1
Location:
Chr8:128685654-128733200 bp, + strand
Genetic Position: Chr8,
76.09 cM, cytoband E2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28266
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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A promoterless neomycin resistance gene fusion was inserted in-frame into exon 2 of the gene. (J:28266)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Hirschsprung disease in mice heterozygous for Itgb1tm1Lscd and Itgb1tm1Ref and hemizygous for Tg(PLAT-cre)116Sdu (J:108439)
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| References |
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Original: |
J:28266
Stephens LE et al.,
"Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality."
Genes Dev 1995 Aug 1;9(15):1883-95
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All: |
12 reference(s)
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Analysis Tools
