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| Nomenclature |
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Symbol:
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Cyp19a1tm1Esi
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Name:
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cytochrome P450, family 19, subfamily a, polypeptide 1;
targeted mutation 1, Evan R Simpson
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MGI ID: |
MGI:2154536 |
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Synonyms: |
ArKO |
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Gene:
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Cyp19a1
Location:
Chr9:54165937-54193442 bp, - strand
Genetic Position: Chr9,
29.49 cM
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Increased adipocyte size in Cyp19a1tm1Esi/Cyp19a1tm1Esi mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48086
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Parent Cell Line:
| KG-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Insertion of a neomycin resistance cassette into exon 9 disrupted the gene. Aromatase activity was not detected in ovaries of 12 week old homozygous mutant mice. (J:48086)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:48086
Fisher CR et al.,
"Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene."
Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6965-70
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All: |
48 reference(s)
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Analysis Tools
