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| Nomenclature |
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Symbol:
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Vcam1tm2Cyb
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Name:
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vascular cell adhesion molecule 1;
targeted mutation 2, Myron Cybulsky
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MGI ID: |
MGI:2153831 |
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Synonyms: |
Vcam1D4D, VCAM-1 D4D |
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Gene:
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Vcam1
Location:
Chr3:116110020-116129688 bp, - strand
Genetic Position: Chr3,
50.17 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69597
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance expression cassette replaced exon 6, which encodes Ig domain 4 and one of two alpha4 integrin binding sites. Expression of all isoforms of the transcript were reduced in homozygous mice compared to wild-type. (J:69597)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Vcam1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:69597
Cybulsky MI et al.,
"A major role for VCAM-1, but not ICAM-1, in early atherosclerosis."
J Clin Invest 2001 May;107(10):1255-62
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All: |
3 reference(s)
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Analysis Tools
