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| Nomenclature |
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Symbol:
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Fgfr2tm2.3Dsn
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 2.3, Clive Dickson
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MGI ID: |
MGI:2153817 |
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Synonyms: |
Fgfr2delta, FgfR2-IIIcdelta |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Growth retardation in Fgfr2tm2.3Dsn/Fgfr2+ mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72517
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele is a derivative of Fgfr2tm2Dsn in which both the exon 9 sequences and the neomycin and thymidine kinase sequences were deleted by crossing mice carrying the Fgfr2tm2Dsn allele to mice which expresss Cre recombinase in the germ line. (J:72517)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:72517
Hajihosseini MK et al.,
"A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes."
Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3855-60
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All: |
4 reference(s)
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Analysis Tools
