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| Nomenclature |
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Symbol:
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Fgfr2tm2Dsn
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 2, Clive Dickson
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MGI ID: |
MGI:2153813 |
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Synonyms: |
FgfR2-IIIcneo-flox |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72517
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP flanked neomycin resistance and thymidine kinase cassette was inserted into intron 8 and a single loxP site was inserted into intron 9. (J:72517)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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Notes |
ES cell line was not specified, but described as "129-derived."
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| References |
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Original: |
J:72517
Hajihosseini MK et al.,
"A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes."
Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3855-60
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All: |
2 reference(s)
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Analysis Tools
