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| Nomenclature |
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Symbol:
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Fgfr2tm1.1Dsn
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 1.1, Clive Dickson
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MGI ID: |
MGI:2153811 |
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Synonyms: |
Fgfr2b-, Fgfr2(IIIb)-, FgfR2-IIIb-Cre |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Palatal abnormalities in Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn and Fgf10tm1Wss/Fgf10tm1Wss mice
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59285
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Parent Cell Line:
| GK129 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is a derivative of Fgfr2tm1Dsn in which exon IIIb was excised in the germline as follows: Cre recombinase was transiently expressed in fertilized C57BL/6 x Fgfr2tm1Dsn/tm1Dsn eggs by injection of an expression vector. Resulting progeny were screened for animals with a deletion of exon IIIb. Abnormally spliced transcripts are produced from this allele that splice exon IIIa to the transmembrane domain and the resulting frameshift is predicted to result in a termination codon in the transmembrane domain of the encoded protein. However, a normal IIIa to IIIc and TM transcript is made and is prediced to result in a normal isoform of the protein. (J:59285)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:59285
De Moerlooze L et al.,
"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis."
Development 2000 Feb;127(3):483-92
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All: |
20 reference(s)
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Analysis Tools
