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| Nomenclature |
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Symbol:
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Abl2tm1Ajk
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Name:
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v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene);
targeted mutation 1, Anthony J Koleske
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MGI ID: |
MGI:2153719 |
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Synonyms: |
arg - |
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Gene:
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Abl2
Location:
Chr1:156558786-156649568 bp, + strand
Genetic Position: Chr1,
67.71 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51887
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The sequences encoding amino acids 287-320, corresponding to the N-terminal portion of the kinase domain, were replaced with a neomycin selection cassette. Western blot analysis demonstrated the absence of the protein in tissue extracts derived from homozygous mice. (J:51887)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abl2 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:51887
Koleske AJ et al.,
"Essential roles for the Abl and Arg tyrosine kinases in neurulation."
Neuron 1998 Dec;21(6):1259-72
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All: |
14 reference(s)
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Analysis Tools
